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This review will present data on several classes of hallucinogens with a particular focus on psychedelics, entactogens, and dissociatives, for which clinical utility has been most extensively documented. However, a growing body of evidence indicates that these drugs may have therapeutic applications beyond their potential for abuse.

Such effects likely contribute to their recreational use. Although these classes do not share a common primary mechanism of action, they do exhibit important similarities in their ability to occasion temporary but profound alterations of consciousness, involving acute changes in somatic, perceptual, cognitive, and affective processes. These include psychedelics, entactogens, dissociatives, and other atypical hallucinogens. Hallucinogens fall into several different classes, as broadly defined by pharmacological mechanism of action, and chemical structure.